Neuroprotective Role of a Novel Copper Chelator against A𝜷₄₂ Induced Neurotoxicity

Figure 3

Histogram shows the percentage of flies with normal, mild, and severe eye phenotypes in ey-GAL4 driven UAS-Aβ ₄₂ flies when grown in normal food (a), copper treated food (b), and Cu + chelator treated food (c). The number of flies (𝑛=100 for (a), (b), and (c)) on y-axes is expressed as % of flies against eye phenotype in each case. Different types of eye degeneration phenotypes of UAS- A𝛽₄₂/ey-GAL4 like mild ((d) ii) and severe ((d) iii, iv) are shown in panel (d). Note that copper supplemented food resulted in severe ommatidial degeneration as indicated by dark patches in the eye (white arrow in (d) iv).

(a)

(b)

(c)

(d)