Alpha 1-Antichymotrypsin, an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer’s Disease, Induces Tau Hyperphosphorylation through c-Jun N-Terminal Kinase Activation
Figure 3
Inflammatory proteins induce tau phosphorylation through JNK activation: JNK phosphorylation in different brain regions—hippocampus (a), cerebral cortex (b), and striatum (c), in mTau, ACT/mTau and ACT/mTau/hTau mice injected with aCSF and IL-1β (1 ng/10 μL) * (aCSF versus IL-1β treated group). Values are normalized to actin levels. The blot above each bar graph shows a representative western blot showing corresponding P-tau in the samples from different mice. The data was collected from four independent mice from each genotype group.