Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction

Figure 2

Cu content in human brain expressed as percentage distribution. The percent distribution of Cu extracted from human frontal cortex in the brain is conserved in AD and HC (total pooled). Box and whisker plots show the range, interquartile range, and median values. No significant difference was observed in the percentage of Cu in each of the corresponding fractions. Between 50–60% of the total Cu in human brain tissue is extractable in the soluble phase. No significant difference was observed between HC (clear boxes) and AD (filled boxes).