In Vivo Characterization of a Novel -Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects
Figure 3
Aβ40 levels over time expressed as a percent of vehicle in plasma and cortex following a single dose of (a) 30 mg/kg or (c) 100 mg/kg of SCH 697466 in TgCRND8 mice. Plasma and brain concentration (μM) of SCH 697466 following a single dose of (b) 30 mg/kg or (d) 100 mg/kg of SCH 697466 in TgCRND8 mice.
