In Vivo Characterization of a Novel -Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects
(a) HES-1, (b) KLF4, and (c) mATH gene expression in the jejunum and (d) HES-1 and (e) KLF4 gene expression in white blood cells following 11 days of q.d. administration (left side of graphs) or 6 days of b.i.d. administration (right side of graphs) of SCH 697466 in nontransgenic B6C3F1 mice. The final dose of SCH 697466 was given 3 hr prior to tissue harvesting. versus vehicle, Dunnett post hoc test.