In Vivo Characterization of a Novel 𝜸-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Table 2

Concentration of SCH 697466 (𝜇M) in plasma and brain for various acute studies in rats, TgCRND8 mice and non-transgenic mice.

Dose (mg/kg)	Rat		TgCRND8 mouse				Nontransgenic mouse
	3 hr post-Treatment time		3 hr post-Treatment time		6 hr post-treatment time		3 hr post-Treatment time
	Plasma	Brain	Plasma	Brain	Plasma	Brain	Plasma	Brain
3	nd	nd	nd	nd	0.05 ± 0.01	0.008 ± 0.002	0.03 ± 0.003	BLOQ
10	0.60 ± 0.07	0.13 ± 0.01	0.68 ± 0.09	0.04 ± 0.004	0.36 ± 0.02	0.06 ± 0.01	0.35 ± 0.05	0.01 ± 0.002
30	2.34 ± 0.16	1.33 ± 0.08	3.13 ± 0.26	0.96 ± 0.22	4.22 ± 1.27	0.36 ± 0.05	1.91 ± 0.12	0.18 ± 0.02
100	4.60 ± 0.39	4.49 ± 0.50	7.79 ± 1.33	9.71 ± 2.95	3.76 ± 1.19	1.99 ± 0.26	6.90 ± 0.81	3.04 ± 0.36

nd: Not done; BLOQ: below the limit of quantification (0.003 𝜇M).