Neprilysin Is Poorly Expressed in the Prefrontal Cortex of Aged Dogs with Cognitive Dysfunction Syndrome
Figure 3
Statistical analysis of the correlation between cortical NEP mRNA expression and the number of cholinergic neurons in basal encephalon (a) and the extent of Aβ deposits in gyrus proreus (b). A positive correlation exists between the number of cholinergic neurons of basal brain with the prefrontal NEP expression (), while no correlation is seen between NEP expression and insoluble Aβ deposits in the same prefrontal cortex (in this diagram, dogs without Aβ deposits belong to the young group). Cognitively healthy dogs are indicated with (o) and aged-cognitively impaired dogs with (▲).
