Research Article
Enhancing Diagnostic Accuracy of aMCI in the Elderly: Combination of Olfactory Test, Pupillary Response Test, BDNF Plasma Level, and APOE Genotype
Table 3
Combination of olfactory deficit, pupillary hypersensitivity response, APOE
, and BDNF plasma level in elderly with aMCI and normal cognition.
| | | aMCI | Normal |
Sv
(%) |
Sp
(%) |
PPV
(%) |
NPV
(%) |
OR
(95% CI) | |
| | Olfactory deficit | | | | | | | | | | (a) Yes | 37 (77.1%) | 11 (22.9%) | 72.6 | 81.0 | 77.1 | 77.1 |
11.29 (4.59–27.76) | <0.0001 | | (b) No | 14 (23.0%) | 47 (77.0%) | | Pupillary hypersensitivity response | | | | | | | | | | (a) Yes | 44 (77.2%) | 13 (22.8%) | 86.3 | 77.6 | 77.2 | 86.5 |
21.76 (7.94–59.65) | <0.0001 | | (b) No | 7 (13.5%) | 45 (86.5%) | | Olfactory deficit and APOE | | | | | | | | | | (a) Yes | 13 (92.9%) | 1 (7.1%) | 26.0 | 98.3 | 92.9 | 60.2 |
19.68 (2.47–156.85) | 0.01 | | (b) No | 37 (39.8%) | 56 (60.2%) | | Olfactory deficit and low BDNF plasma level | | | | | | | | | | (a) Yes | 22 (84.6%) | 4 (15.4%) | 43.1 | 93.1 | 84.6 | 65.1 |
10.24 (3.22–32.57) | <0.0001 | | (b) No | 29 (34.9%) | 54 (65.1%) | | Pupillary hypersensitivity response and APOE | | | | | | | | | | (a) Yes | 13 (76.5%) | 4 (23.5%) | 26.0 | 92.9 | 76.5 | 58.9 |
4.66 (1.41–15.41) | 0.016 | | (b) No | 37 (41.1%) | 53 (58.9%) | | Pupillary hypersensitivity response and low BDNF plasma level | | | | | | | | | | (a) Yes | 20 (79.9%) | 6 (23.1%) | 39.2 | 89.7 | 76.9 | 62.7 |
5.59 (2.03–15.43) | 0.001 | | (b) No | 31 (37.3%) | 52 (62.7%) | | Olfactory deficit and pupillary hypersensitivity response | | | | | | | | | | (a) Yes | 33 (86.8%) | 5 (13.2%) | 64.7 | 91.4 | 86.8 | 74.7 |
19.43 (6.59–57.34) | <0.0001 | | (b) No | 18 (25.4%) | 53 (74.6%) |
|
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Note. APOE 2/4 genotype is not included.
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