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International Journal of Alzheimer’s Disease
Volume 2015, Article ID 903603, 7 pages
http://dx.doi.org/10.1155/2015/903603
Research Article

Inhibitory Effects of Sodium Arsenite and Acacia Honey on Acetylcholinesterase in Rats

1Department of Biochemistry, Cancer Research and Molecular Biology Laboratories, University of Ibadan, Ibadan, Oyo State, Nigeria
2Department of Biochemistry, Ahmadu Bello University, Zaria, Kaduna State, Nigeria

Received 18 November 2014; Revised 21 January 2015; Accepted 27 January 2015

Academic Editor: Cheng-Xin Gong

Copyright © 2015 Aliyu Muhammad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was conducted to investigate the effect of sodium arsenite and Acacia honey on acetylcholinesterase (AChE) activity and electrolytes in the brain and serum of Wistar rats. Male Wistar albino rats in four groups of five rats each were treated with distilled water, sodium arsenite (5 mg/kg body weight), Acacia honey (20% v/v), and sodium arsenite and Acacia honey, daily for one week. The sodium arsenite and Acacia honey significantly decreased AChE activity in the brain with the combined treatment being more potent. Furthermore, sodium arsenite and Acacia honey significantly decreased AChE activity in the serum. Strong correlation was observed between the sodium and calcium ion levels with acetylcholinesterase activity in the brain and serum. The gas chromatography mass spectrometry analysis of Acacia honey revealed the presence of a number of bioactive compounds such as phenolics, sugar derivatives, and fatty acids. These findings suggest that sodium arsenite and/or Acacia honey modulates acetylcholinesterase activities which may be explored in the management of Alzheimer’s diseases but this might be counteracted by the hepatotoxicity induced by arsenics.