Table of Contents Author Guidelines Submit a Manuscript
International Journal of Alzheimer’s Disease
Volume 2015, Article ID 903603, 7 pages
http://dx.doi.org/10.1155/2015/903603
Research Article

Inhibitory Effects of Sodium Arsenite and Acacia Honey on Acetylcholinesterase in Rats

1Department of Biochemistry, Cancer Research and Molecular Biology Laboratories, University of Ibadan, Ibadan, Oyo State, Nigeria
2Department of Biochemistry, Ahmadu Bello University, Zaria, Kaduna State, Nigeria

Received 18 November 2014; Revised 21 January 2015; Accepted 27 January 2015

Academic Editor: Cheng-Xin Gong

Copyright © 2015 Aliyu Muhammad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. C. Chan and J. Huff, “Arsenic carcinogenesis in animals and in humans: mechanistic, experimental, and epidemiological evidence,” Journal of Environmental Science and Health—Part C Environmental Carcinogenesis and Ecotoxicology Reviews, vol. 15, no. 2, pp. 83–122, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Chatterjee, D. Das, and D. Chakraborti, “A study of ground water contamination by arsenic in the residential area of behala, calcutta due to industrial pollution,” Environmental Pollution, vol. 80, no. 1, pp. 57–65, 1993. View at Publisher · View at Google Scholar · View at Scopus
  3. S. E. Owumi, O. A. Odunola, and M. Aliyu, “Co-administration of sodium arsenite and ethanol: protection by aqueous extract of Aframomum longiscapum seeds,” Pharmacognosy Research, vol. 4, no. 3, pp. 154–160, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. O. A. Odunola, K. A. Akinwumi, B. Ogunbiyi, and O. Tugbobo, “Interaction and enhancement of the toxic effects of sodium arsenite and lead acetate in wistar rats,” African Journal of Biomedical Research, vol. 10, no. 1, pp. 59–65, 2007. View at Publisher · View at Google Scholar
  5. A. Sharma, M. K. Sharma, and M. Kumar, “Modulatory role of Emblica officinalis fruit extract against arsenic induced oxidative stress in Swiss albino mice,” Chemico-Biological Interactions, vol. 180, no. 1, pp. 20–30, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Roy, M. Roy, P. K. Pandey, and S. P. Tiwari, “Effects of tissue trace minerals status and histopathological changes in chronic arsenicosis in goats,” Veterinary World, vol. 2, no. 1, pp. 8–9, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. S. S. Vutukuru, N. Arun Prabhath, M. Raghavender, and A. Yerramilli, “Effect of arsenic and chromium on the serum amino-transferases activity in Indian major carp, Labeo rohita,” International Journal of Environmental Research and Public Health, vol. 4, no. 3, pp. 224–227, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. E. García-Chávez, B. Segura, H. Merchant, I. Jiménez, and L. M. del Razo, “Functional and morphological effects of repeated sodium arsenite exposure on rat peripheral sensory nerves,” Journal of the Neurological Sciences, vol. 258, no. 1-2, pp. 104–110, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. F. W. Sunderman Jr., “Recent advances in metal carcinogenesis,” Annals of Clinical and Laboratory Science, vol. 14, no. 2, pp. 93–122, 1984. View at Google Scholar · View at Scopus
  10. J.-H. Li and T. G. Rossman, “Inhibition of DNA ligase activity by arsenite: a possible mechanism of its comutagenesis,” Molecular Toxicology, vol. 2, no. 1, pp. 1–9, 1989. View at Google Scholar · View at Scopus
  11. D. D. Lasko, A. E. Tomkinson, and T. Lindahl, “Eukaryotic DNA ligases,” Mutation Research, vol. 236, no. 2-3, pp. 277–287, 1990. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Tomita, “At the frontline of Alzheimer's disease treatment: γ-secretase inhibitor/modulator mechanism,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 377, no. 4–6, pp. 295–300, 2008. View at Publisher · View at Google Scholar
  13. E. A. Barnard, “Neuromuscular transmission—enzymatic destruction of acetylcholine,” in The Peripheral Nervous System, J. I. Hubbard, Ed., pp. 201–224, Plenum Press, New York, NY, USA, 1974. View at Publisher · View at Google Scholar
  14. D. M. Quinn, “Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states,” Chemical Reviews, vol. 87, no. 5, pp. 955–979, 1987. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Aliyu, O. A. Odunola, A. D. Farooq et al., “Fractionation of Acacia honey affects its antioxidant potential in vitro,” Journal of Acute Disease, pp. 115–119, 2012. View at Google Scholar
  16. M. Aliyu, O. A. Odunola, A. D. Farooq et al., “Acacia honey modulates cell cycle progression, pro-inflammatory cytokines and calcium ions secretion in PC-3 cell lines,” Journal of Cancer Science and Therapy, vol. 4, no. 12, pp. 401–407, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Aliyu, O. A. Odunola, A. D. Farooq et al., “Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line,” Nutrition and Cancer, vol. 65, no. 2, pp. 296–304, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Muhammad, O. A. Odunola, S. E. Owumi et al., “Daily consumption of honey: effects on male wistar albino rats,” International Journal of Food Nutrition and Safety, vol. 1, no. 2, pp. 66–74, 2012. View at Google Scholar
  19. E. Anklam, “A review of the analytical methods to determine the geographical and botanical origin of honey,” Food Chemistry, vol. 63, no. 4, pp. 549–562, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Gheldof, X.-H. Wang, and N. J. Engeseth, “Identification and quantification of antioxidant components of honeys from various floral sources,” Journal of Agricultural and Food Chemistry, vol. 50, no. 21, pp. 5870–5877, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Tchoumboue, J. Awah-Ndukum, F. A. Fonteh, N. D. Dongock, J. Pinta, and Z. A. Mvondo, “Physico-chemical and microbiological characteristics of honey from the Sudano-Guinean zone of West Cameroon,” African Journal of Biotechnology, vol. 6, no. 7, pp. 908–913, 2007. View at Google Scholar · View at Scopus
  22. S. Mohammadzadeh, M. Sharriatpanahi, M. Hamedi, Y. Amanzadeh, S. S. E. Ebrahimi, and S. N. Ostad, “Antioxidant power of Iranian propolis extract,” Food Chemistry, vol. 103, no. 3, pp. 729–733, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Mijanur Rahman, S. H. Gan, and M. I. Khalil, “Neurological effects of honey: current and future prospects,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 958721, 13 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. M. R. Hanaa and M. M. Y. Shaymaa, “Enhancement of the antitumor effect of honey and some of its extracts using adiponectin hormone,” Australian Journal of Basic and Applied Sciences, vol. 5, no. 6, pp. 100–108, 2011. View at Google Scholar
  25. M. Fiorani, A. Accorsi, M. Blasa, G. Diamantini, and E. Piatti, “Flavonoids from Italian multifloral honeys reduce the extracellular ferricyanide in human red blood cells,” Journal of Agricultural and Food Chemistry, vol. 54, no. 21, pp. 8328–8334, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Tripathi and U. C. Srivastava, “Acetylcholineasterase: a versatile enzyme of the nervous system,” Annals of Neurosciences, vol. 15, pp. 106–110, 2008. View at Google Scholar
  27. H. T. Horton, L. A. Moran, K. G. Scrimgeour, M. D. Perry, and D. J. Rawn, Principles of Biochemistry, Pearson Higher Education International, 4th edition, 2006.
  28. A. Liesener, A.-M. Perchuc, R. Schöni, N. H. Schebb, M. Wilmer, and U. Karst, “Screening of acetylcholinesterase inhibitors in snake venom by electrospray mass spectrometry,” Pure and Applied Chemistry, vol. 79, no. 12, pp. 2339–2349, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Stasiuk, A. Janiszewska, and A. Kozubek, “Phenolic lipids affect the activity and conformation of acetylcholinesterase from Electrophorus electricus (Electric eel),” Nutrients, vol. 6, no. 5, pp. 1823–1831, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. J.-J. Liu, D.-L. Li, J. Zhou et al., “Acetylcholine prevents angiotensin II-induced oxidative stress and apoptosis in H9c2 cells,” Apoptosis, vol. 16, no. 1, pp. 94–103, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. M. S. García-Ayllón, M. X. Silveyra, A. Candela et al., “Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation,” Hepatology, vol. 43, no. 3, pp. 444–453, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. W. Burnett, “An assessment of the value of serum cholinesterase as a liver function test and in the diagnosis of jaundice,” Gut, vol. 1, pp. 294–302, 1960. View at Publisher · View at Google Scholar · View at Scopus
  33. G. de Bodt, “Les miels de rhododendrons,” Les Carnets du CARI, no. 50, pp. 10–12, 1996. View at Google Scholar
  34. P. Castaldo, M. Cataldi, S. Magi, V. Lariccia, S. Arcangeli, and S. Amoroso, “Role of the mitochondrial sodium/calcium exchanger in neuronal physiology and in the pathogenesis of neurological diseases,” Progress in Neurobiology, vol. 87, no. 1, pp. 58–79, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. L. N. David and M. C. Michael, Lehninger Principles of Biochemistry, W. H. Freeman, New York, NY, USA, 4th edition, 2005.
  36. M. Prakriya and S. Mennerick, “Selective depression of low-release probability excitatory synapses by sodium channel blockers,” Cell Press, vol. 26, no. 3, pp. 671–682, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. J. J. Clare, S. N. Tate, M. Nobbs, and M. A. Romanos, “Voltage-gated sodium channels as therapeutic targets,” Drug Discovery Today, vol. 5, no. 11, pp. 506–520, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Chiva-Blanch and F. Visioli, “Polyphenols and health: moving beyond antioxidants,” Journal of Berry Research, vol. 2, no. 2, pp. 63–71, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Muhammad, O. A. Odunola, M. A. Gbadegesin, A. M. Adegoke, J. O. Olugbami, and N. S. Uche, “Modulatory role of Acacia honey from north-west Nigeria on sodium arsenite-induced clastogenicity and oxidative stress in male Wistar rats,” Natural Product Research, vol. 29, no. 4, pp. 321–326, 2014. View at Publisher · View at Google Scholar
  40. R. J. Preston, B. J. Dean, S. Galloway, H. Holden, A. F. McFee, and M. Shelby, “Mammalian in vivo cytogenetic assays. Analysis of chromosome aberrations in bone marrow cells,” Mutation Research, vol. 189, no. 2, pp. 157–165, 1987. View at Publisher · View at Google Scholar · View at Scopus
  41. G. L. Ellman, K. D. Courtney, V. Andres Jr., and R. M. Featherstone, “A new and rapid colorimetric determination of acetylcholinesterase activity,” Biochemical Pharmacology, vol. 7, no. 2, pp. 88–95, 1961. View at Publisher · View at Google Scholar · View at Scopus
  42. B. N. Srikumar, K. Ramkumar, T. R. Raju, and B. S. Shankaranarayana Rao, “Assay of acetylcholinesterase activity in the brain,” in Brain and Behavior, pp. 142–144, National Institute of Mental Health and Neuro Sciences, Bangalore, India, 2004. View at Google Scholar
  43. M. Rutkowski and K. Grzegorczyk, “Modifications of spectrophotometric methods for antioxidative vitamins determination convenient in analytic practice,” Acta Scientiarum Polonorum, Technologia Alimentaria, vol. 6, no. 3, pp. 17–28, 2007. View at Google Scholar
  44. M. U. Dahot, M. A. Memon, and M. A. Memon, “UV-spectrophotometric determination of α-tocopherol acetate in pharmaceutical preparations,” Pakistan Journal of Pharmaceutical Sciences, vol. 3, no. 1, pp. 53–59, 1990. View at Google Scholar