Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer’s Disease versus Age-Matched Controls: A Presymptomatic Stage Study

Figure 5

Semiquantitative assessment of GFAP/TSPO colocalization in hippocampal subregions of 3-month-old WT and APPswe/PS1dE9 mice. Quantification of (a) GFAP-IR cells and (b) GFAP/TSPO double-IR cells in CA1-2, CA3, and DG hippocampal subregions in WT ( = 3) and APPswe/PS1dE9 ( = 5) mice. Results were expressed as mean cell count per unit area (mm²) for each mouse; indicates and indicates . NTg: wild type; Tg: APPswe/PS1dE9.

(a)

(b)