Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia

Table 2

The association of depressive symptoms with mortality in patients with mild dementia.

	Number of deaths	Model 1	value	Model 2	value	Model 3	value
		HR (95% CIs)		HR (95% CIs)		HR (95% CIs)
No or few depressive symptoms; (Cornell score of 0–7)	38	1	—	1	—	1	—
Moderate depressive symptoms; (Cornell score of 8–10)	6	0.68 (0.29–1.61)	0.384	0.70 (0.28–1.75)	0.446	0.48 (0.17–1.37)	0.172
Major depressive symptoms; (Cornell score of > 10)	12	2.55 (1.33–4.87)	0.005	2.13 (1.05–4.34)	0.037	2.50 (1.03–6.06)	0.042

Model 1: crude analysis without adjustment for potential confounders.
Model 2: multivariable analysis adjusted for age, sex, smoking status, alcohol consumption, education, BMI, household status, MMSE, CCI, and RCT.
Model 3: multivariable analysis adjusted for all the confounders in model 2 and Qol-AD, NPIQ, and ADSC-ADL, treatment with antidepressants within 12 months.
HR = hazard ratio. 95% CIs = 95% confidence intervals.