Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer’s Disease

Figure 2

Progressive impairment of contextual fear conditioning in PS2Tg2576 mice with aging. The fear memory 24 hr after footshock was evaluated in PS2Tg2576 mice (closed column, ) and their littermate control mice (open column, ). PS2Tg2576 mice display impaired memory for context after fear conditioning beginning as early as 4 months of age, with a trend for an impairment observed at 3 months. Data points represent the mean ± SEM. , versus the corresponding wild-type group.