Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer’s Disease

Figure 3

Contextual fear conditioning in the Tg2576 mice. The fear memory 24 hr after footshock was evaluated in Tg2576 mice (closed column, ) and their littermate control mice (open column, ). Tg2576 mice display intact contextual memory 24 hr later at 3 and 4 months of age. A significant impairment of contextual fear conditioning is observed, with lower levels of freezing to context in 6-month-old Tg2576 mice compared to controls. The impairment is also significant in 10-month-old Tg2576 mice. No differences were observed in freezing to context in control mice across all ages examined. Data points represent the mean ± SEM. versus the corresponding wild-type group.