The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer’s Disease

Table 1

Demographic, clinical, and PET data.

Subject no.	1	2	3	4	5	6	Median [range]
Age (years)	70	67	73	54	85	80
Gender (F/M)	F	M	M	M	M	M	(1/5)
CDR	1	0.5	0.5	0.5	0.5	0.5
SOB	5.5	3.5	2	2.5	1.5	2.5
MMSE	19	25	25	27	26	27
AD/MCI	AD	AD	MCI	AD	AD	AD	(5/1)
Disease dur. (months)	10	3		9	20	13
Pre-post scan duration (month)	9.5	1.1	0.6	1.1	13.8	4.0
PiB SUVR:							Mean [95 CI]
Visual pre	3.13	2.12	1.27	2.39	1.67	1.18
Visual post	3.41	2.10	1.39	2.14	1.61	1.22
Difference (%)	9.0 %	-1.3 %	9.5 %	-10.6 %	-3.2 %	4.0 %	1.2 %
Vis. Ass pre	2.83	2.10	1.45	2.07	1.89	1.34
Vis. Ass post	3.21	1.99	1.58	1.84	1.92	1.35
Difference (%)	13.4 %	-5.0 %	9.2 %	-11.4 %	1.7 %	1.1 %	1.5 %
Parietal pre	2.73	2.80	2.38	2.94	2.54	1.74
Parietal post	2.99	2.71	2.83	2.57	2.34	1.83
Difference (%)	9.6 %	-3.3 %	18.9 %	-12.6 %	-7.9 %	5.2 %	4.4 %
Precuneus pre	3.31	3.19	2.26	3.44	2.59	2.10	2.81
Precuneus post	3.58	2.95	2.72	2.96	2.83	2.19	2.87
Difference (%)	8.1 %	-7.5 %	20.0 %	-13.8 %	9.1 %	4.4 %	3.4 %
Post. Cing. Pre	3.25	3.26	2.41	3.61	2.56	1.95	2.84
Post. Cing. Post	3.54	3.19	2.94	3.09	2.63	2.12	2.92
Difference (%)	8.8 %	-2.3 %	22.1 %	-14.4 %	2.8 %	9.0 %	4.3 %
Global pre	2.87	2.57	2.00	2.69	2.19	1.61
Global post	3.17	2.46	2.33	2.35	2.30	1.67
Difference (%)	10.6 %	-4.1 %	16.5 %	-12.5	5.4 %	4.1 %

CDR: Clinical Dementia Rating; SOB: CDR sum-of-boxes; MMSE: minimental state examination; AD: Alzheimer’s disease; MCI, mild cognitive impairment; SUVR: standardized uptake value ratio; pre: before light stimulation; post: after light stimulation.