Structural Brain Imaging Phenotypes of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) Found by Hierarchical Clustering

Figure 10

Cluster 8 shows on average significantly more cortical and also subcortical atrophy than cluster 9. All cluster 8 subjects are males, and the baseline ADAS score was the highest of all MCI clusters. Yet, the ADAS slope is highest, i.e., the longitudinal decline of cluster 9 is the worst of all MCI clusters. Transverse and coronal views are shown in Supplementary Results (Figures 9 b and 9 c). The FDR value is 0.00786.