Structural Brain Imaging Phenotypes of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) Found by Hierarchical Clustering

Figure 4

Results of voxel-wise -tests of gray matter distributions between clusters 1 and 2 in Figure 1. The FDR corresponding to threshold was 0.143. Average -values were not high and differences between the clusters occurred in a scattered manner suggesting that the clusters 1 and 2 manifested similar (typical) AD pathogenesis. Further results (not shown) revealed that clusters 1-4 show a lot of similarity and most likely manifest the typical AD pathogenesis.