Trends in Healthcare Resource Use Preceding Diagnosis of Alzheimer’s Disease Dementia
Table 2
Comorbid medical conditions at matching (year 1 preindex) and in the 1-year period immediately prior to first observed diagnosis of Alzheimer’s disease (year 5 preindex).
Year 1 preindex (matching period)
Year 5 preindex (AD diagnosis period)
a
AD
Non-AD
AD
Non-AD
%
%
%
%
Congestive heart failure
1,981
7.3%
1,968
7.2%
4,099
15.0%
2,874
10.5%
<0.001
Cardiac arrhythmia
3,427
12.5%
3,318
12.2%
6,305
23.1%
4,671
17.1%
<0.001
Valvular disease
1,550
5.7%
1,484
5.4%
2,845
10.4%
1,919
7.0%
<0.001
Pulmonary circulatory disorder
444
1.6%
428
1.6%
1,145
4.2%
919
3.4%
<0.001
Peripheral vascular disease
2,798
10.2%
2,715
9.9%
5,381
19.7%
4,514
16.5%
<0.001
Hypertension (uncomplicated)
15,804
57.9%
15,603
57.1%
18,864
69.1%
16,317
59.8%
<0.001
Hypertension (complicated)
2,285
8.4%
2,231
8.2%
4,877
17.9%
3,933
14.4%
<0.001
Paralysis
105
0.4%
100
0.4%
327
1.2%
73
0.3%
<0.001
Other neurological disorders
945
3.5%
335
1.2%
4,007
14.7%
366
1.3%
<0.001
Chronic obstructive pulm. disease
3,318
12.2%
3,300
12.1%
4,982
18.2%
4,422
16.2%
<0.001
Diabetes (uncomplicated)
6,350
23.3%
6,205
22.7%
6,983
25.6%
6,407
23.5%
<0.001
Diabetes (complicated)
2,401
8.8%
2,401
8.8%
4,366
16.0%
3,955
14.5%
<0.001
Hypothyroidism
3,819
14.0%
3,676
13.5%
5,506
20.2%
4,593
16.8%
<0.001
Renal failure
3,110
11.4%
3,071
11.2%
6,459
23.7%
6,104
22.4%
<0.001
Liver failure
271
1.0%
259
0.9%
486
1.8%
373
1.4%
<0.001
Peptic ulcer disease
122
0.4%
99
0.4%
241
0.9%
104
0.4%
<0.001
HIV/AIDS
<10
<10
<10
<10
Lymphoma
110
0.4%
118
0.4%
201
0.7%
186
0.7%
0.444
Metastatic cancer
74
0.3%
62
0.2%
140
0.5%
174
0.6%
0.054
Solid tumor: No metastasis
1,624
5.9%
1,603
5.9%
1,831
6.7%
1,918
7.0%
0.141
Rheumatoid arthritis
847
3.1%
837
3.1%
1,072
3.9%
979
3.6%
0.036
Coagulopathy
366
1.3%
350
1.3%
902
3.3%
549
2.0%
<0.001
Obesity
767
2.8%
741
2.7%
1,281
4.7%
1,372
5.0%
0.070
Weight loss
493
1.8%
483
1.8%
1,615
5.9%
413
1.5%
<0.001
Fluid electrolyte disorders
1,523
5.6%
1,476
5.4%
4,033
14.8%
1,435
5.3%
<0.001
Blood loss anemia
142
0.5%
127
0.5%
294
1.1%
142
0.5%
<0.001
Deficiency anemia
915
3.4%
914
3.3%
1,682
6.2%
1,069
3.9%
<0.001
Alcohol abuse
163
0.6%
148
0.5%
329
1.2%
144
0.5%
<0.001
Drug abuse
248
0.9%
254
0.9%
516
1.9%
397
1.5%
<0.001
Psychoses
283
1.0%
234
0.9%
1,232
4.5%
120
0.4%
<0.001
Depression
2,369
8.7%
2,249
8.2%
5,394
19.8%
2,150
7.9%
<0.001
a value is from chi-square test for the preindex year 5 comparison between AD dementia and non-AD cohorts. Abbreviations: AD: Alzheimer’s disease.
