International Journal of Alzheimer’s Disease

Neuroinflammation, AD, and Dementia


Publishing date
01 Sep 2010
Status
Published
Submission deadline
01 Mar 2010

Lead Editor

1Department of Oncology and Neurosciences, University “G. D'Annunzio” Chieti-Pescara, Italy

2Department of Neurology, Hadassah Hebrew University Medical Center, P.O. Box 12000, Jerusalem 91120, Israel

3Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD, USA

4Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, 8331150, Santiago, Chile

5Neurological Service and Memory Clinic, Tel-Aviv University, Bat-yam, Israel


Neuroinflammation, AD, and Dementia

Description

Increasing basic science and clinical evidence implicates inflammatory processes that result in glial activation in the pathogenesis of Alzheimer's disease. Immunohistochemical studies have shown that the plaques and tangles of AD are heavily infiltrated with activated glial cells, in addition to inflammatory factors, such as cytokines, chemokines, complement components, and acute phase proteins that colocalize as secondary components in senile plaques or are overproduced in AD brains. The importance of inflammation in AD is affirmed by data showing polymorphisms in cytokines and other immune molecules in people afflicted with AD, and epidemiological studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) diminish the risk of developing AD. Activation of inflammatory pathways early or preceding the disease would provide support for a causative role for inflammation; although inflammation could still be a key driving force and accelerate AD progression if activated at a later stage of the disease.

We invite authors to contribute original research articles as well as review articles that stimulate the continuous effort to define the role of inflammation in AD as well as provide a more complete risk assessment, therefore, allowing a new approach for prevention, treatment, and interventions to retard disease progression.

The topics to be covered include, but are not limited to:

  • Cholinergic anti-inflammatory signalling
  • Peripheral inflammatory biomarkers in AD
  • Immunotherapy in the treatment of AD
  • Why block inflammation in AD?
  • Genetic basis of a specific inflammatory disease: Alzheimer's disease
  • Neuroinflammation and cognitive functions in CNS diseases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 974026
  • - Editorial

Neuroinflammation, AD, and Dementia

Marcella Reale | Talma Brenner | ... | Diana Paleacu
  • Special Issue
  • - Volume 2010
  • - Article ID 854527
  • - Research Article

Intereleukin-10 Promoter Polymorphism in Mild Cognitive Impairment and in Its Clinical Evolution

Beatrice Arosio | Luigina Mastronardi | ... | Giorgio Annoni
  • Special Issue
  • - Volume 2010
  • - Article ID 587463
  • - Review Article

Microglial Immunoreceptor Tyrosine-Based Activation and Inhibition Motif Signaling in Neuroinflammation

Bettina Linnartz | Yiner Wang | Harald Neumann
  • Special Issue
  • - Volume 2010
  • - Article ID 274128
  • - Review Article

Amyloid-Beta Peptide, Oxidative Stress and Inflammation in Alzheimer's Disease: Potential Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids

S. C. Dyall
  • Special Issue
  • - Volume 2010
  • - Article ID 732806
  • - Review Article

Neuroinflammation, Microglia and Implications for Anti-Inflammatory Treatment in Alzheimer's Disease

Daniela L. Krause | Norbert Müller
  • Special Issue
  • - Volume 2010
  • - Article ID 798424
  • - Research Article

Effects of Immunomodulatory Substances on Phagocytosis of A 𝛽 𝟏 - 𝟒 𝟐 by Human Microglia

Erik Hjorth | Dan Frenkel | ... | Marianne Schultzberg
  • Special Issue
  • - Volume 2010
  • - Article ID 501541
  • - Research Article

Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease

S. Duleu | A. Mangas | ... | M. Geffard
International Journal of Alzheimer’s Disease
 Journal metrics
Acceptance rate17%
Submission to final decision100 days
Acceptance to publication36 days
CiteScore3.800
Impact Factor-
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