International Journal of Alzheimer’s Disease

Animal Models of Alzheimer's Disease


Publishing date
15 Oct 2010
Status
Published
Submission deadline
15 Apr 2010

Lead Editor

1Case Western Reserve University School of Medicine, Ohio, USA

2Department of Cell biology, Microbiology and Molecular biology, University of South Florida, Florida, USA

3Neurobiology and Behavior School of Biological Sciences, Institute for Brain Aging and Dementia, UC Irvine, California, USA

4Department of Neurology, The University of Tennessee Health Science Center, Tennessee, USA


Animal Models of Alzheimer's Disease

Description

The necessity for a deeper understanding of neurological diseases such as Alzheimer's disease (AD) that increase in frequency as a function of age has become of paramount importance with the coming of age of the baby boom generation as well as the increasing social demands for individuals to perform better and longer. AD is characterized by a gradual decline in cognitive function and presence of pathological inclusions such as Aβ plaques and neurofibrillary tangles composed of hyperphosphorylated tau in the brain. These are the main hallmarks of the disease and focus of most current therapeutic strategies. As such, the development of transgenic and nontransgenic models of AD over the last decade has primarily focused on these pathological markers. These models have become promising tools to decipher the mechanistic importance of tau phosphorylation and Aβ deposits, as well the relationship between each other, other pathological AD-related events, and cognitive loss. However, while seemingly obvious, it is important to remember that the validity of an animal model of disease is tightly linked to the ability of the animal to mimic the signs of the disease–which goes beyond the pathology and needs to include cognitive decline and neuronal loss. This special issue seeks to provide an updated and critical evaluation of the available animal models of AD with the primary goal to deepen our mechanistic understanding of AD and elucidate how the development of these models has led or can lead to novel therapies for AD patients.

We invite authors to present original research articles as well as review articles that will encourage the primary goals of this special issues. We are interested in manuscripts that focus on novel animal models (transgenic or nontransgenic) and novel therapeutic strategies tested in such mouse models. While the majority of the work is carried out in rodents, we also welcome manuscripts that focus on nonrodent models of AD.

The topics to be covered include, but are not limited to:

  • Development of novel transgenic or nontransgenic animal models of AD (rodents or other)
  • Mechanistic studies of AD-related pathology in animal models including, but not limited to, APP/Aβ and/or tau hyperphosphorylation (i.e., oxidative stress, mitochondrial, inflammatory, cell cycle changes etc.)
  • Development of novel behavioral or translational methodologies to determine impairment in models of AD
  • Novel therapeutic approaches to modulate AD pathology and cognitive impairment

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 606357
  • - Editorial

Animal Models of Alzheimer's Disease

Gemma Casadesus | Gary Arendash | ... | Mike McDonald
  • Special Issue
  • - Volume 2010
  • - Article ID 954589
  • - Research Article

Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory

E. I. Zakharova | Z. I. Storozheva | ... | A. A. Kubatiev
  • Special Issue
  • - Volume 2010
  • - Article ID 604792
  • - Research Article

Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer's Disease

Wayne Chadwick | Randall Brenneman | ... | Stuart Maudsley
  • Special Issue
  • - Volume 2010
  • - Article ID 749061
  • - Research Article

Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases

L. Trofimova | M. Lovat | ... | V. Bunik
  • Special Issue
  • - Volume 2010
  • - Article ID 128354
  • - Research Article

Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice

Lydia Giménez-Llort | Yoelvis García | ... | Coral Sanfeliu
  • Special Issue
  • - Volume 2010
  • - Article ID 864625
  • - Research Article

Ablation of the Locus Coeruleus Increases Oxidative Stress in Tg-2576 Transgenic but Not Wild-Type Mice

Orest Hurko | Kurt Boudonck | ... | Daniel Crowther
  • Special Issue
  • - Volume 2010
  • - Article ID 604853
  • - Review Article

In Vivo Imaging Biomarkers in Mouse Models of Alzheimer's Disease: Are We Lost in Translation or Breaking Through?

Benoît Delatour | Stéphane Epelbaum | ... | Marc Dhenain
  • Special Issue
  • - Volume 2010
  • - Article ID 621870
  • - Review Article

Alzheimer's Proteins, Oxidative Stress, and Mitochondrial Dysfunction Interplay in a Neuronal Model of Alzheimer's Disease

Antonella Bobba | Vito A. Petragallo | ... | Anna Atlante
  • Special Issue
  • - Volume 2010
  • - Article ID 417314
  • - Research Article

Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model

An Tanghe | Annelies Termont | ... | Tom Van Dooren
  • Special Issue
  • - Volume 2010
  • - Article ID 576357
  • - Research Article

Grape-Seed Polyphenolic Extract Improves the Eye Phenotype in a Drosophila Model of Tauopathy

Cathie M. Pfleger | Jun Wang | ... | Giulio M. Pasinetti
International Journal of Alzheimer’s Disease
 Journal metrics
Acceptance rate17%
Submission to final decision100 days
Acceptance to publication36 days
CiteScore3.800
Impact Factor-
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.