International Journal of Alzheimer’s Disease

Copper Status in Alzheimer's Disease and other Neurodegenerative Disorders: Genetics, Mechanisms, Neurophysiology, and Therapies


Publishing date
01 Nov 2011
Status
Published
Submission deadline
01 May 2011

Lead Editor

1Department of Neuroscience, AFaR, Ospedale Fatebenefratelli, Isola Tiberina, Rome, Italy

2Department of Neurology, University Hospital Utrecht, Utrecht, The Netherlands

3Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA

4Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, 5022 Kresge Building II, Ann Arbor, MI, USA


Copper Status in Alzheimer's Disease and other Neurodegenerative Disorders: Genetics, Mechanisms, Neurophysiology, and Therapies

Description

Alzheimer's disease (AD) is a leading cause of death worldwide. It is a genetically heterogeneous syndrome which includes a broad spectrum of phenotypes. Recent advances in biology and medicine have introduced metals, particularly copper, as influencing agents in AD, thus improving understanding of the mechanisms and electrophysiology underlying the pathology. Increasing information has led to the development of new models or tools to characterize defective pathways of copper trafficking linked to neurodegenerative processes and the rational for phase II and III clinical trials as well.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathology underlying copper involvement in AD. Potential topics include, but are not limited to:

  • Advances in metal toxicity as well as genetics of AD
  • Latest technologies or strategies to point out metallobiological processes subtending typical deficits of AD
  • Role of inflammation related to copper status in AD
  • Metal-proteins interplay in AD, in mild cognitive impairment, and in other copper diseases of neurodegeneration other than AD
  • Recent advances in drug strategy based on metallobiology of AD as well as biological molecules which induce or maintain a state of copper malabsorption
  • The increased toxicity of oral ingestion of inorganic copper (such as in drinking water or copper supplements) relative to organically bound copper in food
  • The interaction of lipids, for example, from a high fat diet, and copper in producing neurotoxicity
  • The mechanisms whereby aging increases susceptibility to copper toxicity in the brain

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 903940
  • - Editorial

Copper Status in Alzheimer's Disease and Other Neurodegenerative Disorders: Genetics, Mechanisms, Neurophysiology, and Therapies

Rosanna Squitti | D. Larry Sparks | ... | George J. Brewer
  • Special Issue
  • - Volume 2011
  • - Article ID 539762
  • - Research Article

On the Involvement of Copper Binding to the N-Terminus of the Amyloid Beta Peptide of Alzheimer's Disease: A Computational Study on Model Systems

Samira Azimi | Arvi Rauk
  • Special Issue
  • - Volume 2011
  • - Article ID 292593
  • - Research Article

Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin

Franca Tecchio | Giovanni Assenza | ... | Rosanna Squitti
  • Special Issue
  • - Volume 2011
  • - Article ID 345614
  • - Review Article

Disturbed Copper Bioavailability in Alzheimer's Disease

Daniela Kaden | Ashley I. Bush | ... | Gerd Multhaup
  • Special Issue
  • - Volume 2011
  • - Article ID 864753
  • - Research Article

Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices

Nina L. Salazar-Weber | Jeffrey P. Smith
  • Special Issue
  • - Volume 2011
  • - Article ID 150916
  • - Research Article

Gender Effects on Plasma and Brain Copper

Joseph F. Quinn | Christopher Harris | ... | Martina Ralle
  • Special Issue
  • - Volume 2011
  • - Article ID 706576
  • - Research Article

The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors

Ramón A. Lorca | Lorena Varela-Nallar | ... | J. Pablo Huidobro-Toro
  • Special Issue
  • - Volume 2011
  • - Article ID 492686
  • - Review Article

Paradigm Shift in Treatment of Alzheimer's Disease: Zinc Therapy Now a Conscientious Choice for Care of Individual Patients

Tjaard U. Hoogenraad
  • Special Issue
  • - Volume 2011
  • - Article ID 537528
  • - Review Article

Issues Raised Involving the Copper Hypotheses in the Causation of Alzheimer's Disease

George J. Brewer
  • Special Issue
  • - Volume 2011
  • - Article ID 370345
  • - Review Article

Copper Modulation as a Therapy for Alzheimer's Disease?

Yasmina Manso | Gemma Comes | ... | Paul A. Adlard
International Journal of Alzheimer’s Disease
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