International Journal of Alzheimer’s Disease

Neuroprotection and Neuroregeneration in Alzheimer's Disease

Publishing date
01 May 2012
Submission deadline
01 Nov 2011

Lead Editor

1Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, FL, USA

2Department of Pharmacology, Ruth and Bruce Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Haifa, Israel

3Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden

Neuroprotection and Neuroregeneration in Alzheimer's Disease


Brain aging and age-related neurodegenerative disorders have complex etiology and pathology. The link between healthy aging and age-related disorders is still not clear. Neurodegeneration in Alzheimer's disease (AD) is thought to be initiated by a cascade of neurotoxic events that includes oxidative stress, brain iron dysregulation, glutamate excitotoxicity, nitric oxide, inflammatory process, and neurotoxic processing resulting from misfolding and aggregation of Aβ-peptide, as a possible consequence of the demise of ubiquitin-proteasome system, demonstrated neurochemically and by transcriptomics and proteomic profiling. Although AD patients are benefiting from current symptomatic therapies, they have limitation in their ability to modify the course of the disease. Although many drugs have demonstrated the ability to be neuroprotective in the laboratory, they failed in clinical trials. AD models employed in vitro and in vivo are not a true representation of complex diseases seen in patients. Most efforts have been in the direction of preventing deposition of Aβ-peptide in transgenic mice without pathological process of AD. The complex pathology of AD implies that multiple causes with singular drug treatment may not be sufficient as therapeutic. The new therapeutic strategies for AD should act on multiple neural and biochemical targets involved in the neurodegenerative process.

Current advancement of stem cell research gives hope toward future application to AD therapies. However, without understanding the complex pathological condition of this disease, effective neuroregeneration may not be accomplished.

The present special issue focuses on novel pathways in neurodegeneration and current trends in drug targets and stem cells. Potential topics include, but are not limited to:

  • Describing various cellular and animal AD models and discussing pros and cons
  • Describing developed drugs which failed or are in the clinic
  • Discussing concepts for developing multitarget neuroprotective and/or neuroregenerative drugs
  • Describing stem cell therapies as a neuroregenerative approach
  • Discussing combined therapeutic approaches of stem cells and drugs

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2012
  • - Article ID 864138
  • - Editorial

Neuroprotection and Neuroregeneration in Alzheimer's Disease

Kiminobu Sugaya | Moussa B. H. Youdim | ... | K. S. Jagannatha Rao
  • Special Issue
  • - Volume 2012
  • - Article ID 459806
  • - Research Article

Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-ß: A Protective Role of Melatonin

Sergio A. Rosales-Corral | Gabriela Lopez-Armas | ... | Russel J. Reiter
  • Special Issue
  • - Volume 2012
  • - Article ID 684283
  • - Review Article

Alternative Strategy for Alzheimer’s Disease: Stress Response Triggers

Joan Smith Sonneborn
  • Special Issue
  • - Volume 2012
  • - Article ID 568382
  • - Review Article

Neuroprotection and Neurodegeneration in Alzheimer’s Disease: Role of Cardiovascular Disease Risk Factors, Implications for Dementia Rates, and Prevention with Aerobic Exercise in African Americans

Thomas O. Obisesan | Richard F. Gillum | ... | John Kwagyan
  • Special Issue
  • - Volume 2012
  • - Article ID 258454
  • - Review Article

Hormone Replacement Therapy and Risk for Neurodegenerative Diseases

Richelin V. Dye | Karen J. Miller | ... | Andrew J. Levine
  • Special Issue
  • - Volume 2012
  • - Article ID 734956
  • - Review Article

The Complexity of Sporadic Alzheimer’s Disease Pathogenesis: The Role of RAGE as Therapeutic Target to Promote Neuroprotection by Inhibiting Neurovascular Dysfunction

Lorena Perrone | Oualid Sbai | ... | Angelika Bierhaus
International Journal of Alzheimer’s Disease
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