International Journal of Alzheimer’s Disease

Metals and Alzheimer's Disease


Publishing date
15 Mar 2011
Status
Published
Submission deadline
15 Sep 2010

1Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia

2Metalloproteins Unit, CNR-Institute for Biomedical Technologies, University of Padova, V.le G. Colombo 3, 35121 Padova, Italy

3Laboratoire de Chimie de Coordination 205, route de Narbonne, 31077 Toulouse Cedex, France

4Section of Geriatrics & Gerontology, UW Madison Medical School VA Hospital, GRECC 11G, 2500 Overlook Terrace, Madison, WI 53705, USA


Metals and Alzheimer's Disease

Description

The factors that lead to onset and progression of Alzheimer's disease are still not well understood. Over recent decades there has been increasing evidence for altered metal homeostasis as a major factor in neuropathological and cognitive changes in Alzheimer's disease as well as several other major neurodegenerative illnesses. Early studies have shown a potential role for aluminium in neurodegeneration, and the role of iron in neuronal redox-associated toxicity is well known. Recent reports describe a role for copper and zinc in amyloid beta peptide expression, aggregation, and degradation. Importantly, the growing knowledge of how metal metabolism is altered in Alzheimer's disease and related neurodegenerative disorders is leading to the development of novel and exciting drug development strategies to improve the lives of Alzheimer's disease patients.

In this special issue we are seeking manuscripts covering a broad range of exciting and informative views on topics related to metals and Alzheimer's disease. These may include historical perspectives, the current status of novel research into the role of metals in neurodegeneration, identification of alternative metals that may be altered in Alzheimer's disease, development of new technologies for probing metals in Alzheimer's disease or neurodegeneration, or development of unique drug strategies to modulate metal homeostasis. The main topics include, but are not limited to:

  • Historical perspectives on Metals and Alzheimer's disease or neurodegeneration
  • Metals and amyloid
  • Metals and neurotoxicity
  • Metals and glia
  • Therapies to modulate metal homeostasis
  • Identification of new metals associated with Alzheimer's disease
  • Advances in knowledge on copper, zinc, iron, or aluminium in Alzheimer's disease
  • New techniques and tools to investigate the role of metals in neurodegeneration

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 659424
  • - Editorial

Metals and Alzheimer's Disease

Anthony R. White | Peter Faller | ... | Paolo Zatta
  • Special Issue
  • - Volume 2011
  • - Article ID 276393
  • - Review Article

Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses

Masahiro Kawahara | Midori Kato-Negishi
  • Special Issue
  • - Volume 2011
  • - Article ID 542043
  • - Review Article

Alzheimer's Disease and Metals: A Review of the Involvement of Cellular Membrane Receptors in Metallosignalling

Pavithra C. Amadoruge | Kevin J. Barnham
  • Special Issue
  • - Volume 2011
  • - Article ID 607861
  • - Research Article

Correlation of Copper Interaction, Copper-Driven Aggregation, and Copper-Driven H2O2 Formation with Aβ40 Conformation

Chia-Anne Yang | Yung-Han Chen | ... | Yi-Cheng Chen
  • Special Issue
  • - Volume 2011
  • - Article ID 950932
  • - Research Article

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Michael Ho | David E. Hoke | ... | Geneviève Evin
  • Special Issue
  • - Volume 2011
  • - Article ID 231595
  • - Research Article

Ceruloplasmin/Transferrin Ratio Changes in Alzheimer's Disease

Rosanna Squitti | Carlo Salustri | ... | Paolo M. Rossini
  • Special Issue
  • - Volume 2011
  • - Article ID 607543
  • - Review Article

Lead, Manganese, and Methylmercury as Risk Factors for Neurobehavioral Impairment in Advanced Age

Bernard Weiss
  • Special Issue
  • - Volume 2011
  • - Article ID 208634
  • - Research Article

New Proteins Found Interacting with Brain Metallothionein-3 Are Linked to Secretion

Issam El Ghazi | Bruce L. Martin | Ian M. Armitage
  • Special Issue
  • - Volume 2011
  • - Article ID 720658
  • - Review Article

Iron and Mechanisms of Neurotoxicity

Gabriela A. Salvador | Romina M. Uranga | Norma M. Giusto
  • Special Issue
  • - Volume 2011
  • - Article ID 971021
  • - Review Article

The Role of Zinc in Alzheimer's Disease

Nicole T. Watt | Isobel J. Whitehouse | Nigel M. Hooper
International Journal of Alzheimer’s Disease
 Journal metrics
Acceptance rate17%
Submission to final decision100 days
Acceptance to publication36 days
CiteScore3.800
Impact Factor-
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.