Aß Behavior on Neuronal Membranes: Aggregation and Toxicities
1Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522, Japan
2Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2M), Université de la Méditerranée Aix-Marseille II et Université Paul Cézanne Aix-Marseille III, CNRS UMR 6231, INRA USC 2027, France
3Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, TMDT 4-305, 101 College Street, Toronto, ON, Canada M5G 1L7
4Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, 4025 Basel, Switzerland
Aß Behavior on Neuronal Membranes: Aggregation and Toxicities
Description
Aggregation and deposition of amyloid β-protein (Aβ) in brain is an invariable and initial event in the pathological process of Alzheimer's disease. Thus, one of the fundamental challenges regarding pathogenesis of Alzheimer's disease is to elucidate how Aβ starts to aggregate and how aggregated Aβ causes its toxicities against neurons. Recently, a body of evidence is growing that Aβ aggregation is facilitated in the presence of particular membranes lipids such as gangliosides and cholesterol and furthermore, that Aβ toxicities emerge through interaction with specific neuronal membrane microdomains such as lipid rafts.
We invite investigators to contribute original research articles as well as review articles that will provide novel information on this research area and stimulate research activities to understand the basic mechanism underlying early pathogenesis of Alzheimer's disease.
Potential topics include, but are not limited to:
- Aβ interaction with cholesterol and sphingolipids
- Effect of cholesterol on Aβ-membrane interaction
- Aβ conformational changes on neuronal membranes (lipid rafts)
- Aβ aggregation/oligomerization on neuronal membranes (lipid rafts)
- Aβ toxicities on neuronal or intraneuronal membranes/organelles (e.g., mitochondria and ER)
- Aβ-induced ion channel formation
- Structure of Aβ oligomers in membranes: theoretical and experimental studies
- Internalization of Aβ in neuronal cells
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