Differential Gene Expression in Primary Breast Tumors Associated with Lymph Node Metastasis

Table 2

Fifteen probes demonstrating significant differences in expression level between tumors with and without lymph node metastases. KIAA1609 and SLC27A2 were represented by multiple probes.

Gene symbol	Accession number	Gene name	Probe ID	𝑃 value	Fold-change
Genes downregulated in node-positive primary tumors
ABCC8	NM_000352	ATP-binding cassette, subfamily C (CFTR/MRP), member 8	210246_s_at	.000889	1.67
BATF	NM_006399	Basic leucine zipper transcription factor, ATF-like	205965_at	.000874	1.51
IGFBP6	NM_002178	Insulin-like growth factor binding protein 6	203851_at	.000679	1.55
MRPL40	NM_003776	Mitochondrial ribosomal protein L40	203152_at	2.14E-05	1.57
SLC27A2	NM_003645	Solute carrier family 27 (fatty acid transporter), member 2	205768_s_at	.000413	2.34
			205769_at	.000921	2.12
Genes upregulated in node-positive primary tumors
—^a	AL050145		215526_at	.000477	1.55
AURKA	NM_198433	Aurora kinase A	208079_s_at	.000512	1.80
KIAA1609	NM_020947	KIAA1609	221843_s_at	1.25E-05	1.66
			65438_at	1.53E-05	1.73
KIF23	NM_138555	Kinesin family member 23	204709_s_at	.000675	1.82
PLCB1	NM_015192	Phospholipase C, beta 1 (phosphoinositide-specific)	213222_at	.000612	2.05
RPL13	NM_033251	Ribosomal protein L13	214976_at	.000129	1.64
TCP1	NM_030752	T-complex 1	208778_s_at	.000183	1.51
TGFA	NM_003236// NM_001099691^b	Transforming growth factor, alpha	205016_at	.000233	1.77

^aThis probe corresponds to UniGene cluster HS.225986 but not to a known gene.
^bThis probe represents both isoforms 1 and 2 of the TGFA gene.