A Comparative Analysis of Biomarker Expression and Molecular Subtypes of Pure Ductal Carcinoma In Situ and Invasive Breast Carcinoma by Image Analysis: Relationship of the Subtypes with Histologic Grade, Ki67, p53 Overexpression, and DNA Ploidy

Table 2

A comparison of biomarker expression in pDCIS versus IBCA.

Tumor biomarkers	pDCIS	IBCA	𝑃 value*
ER+	97 (82.2%)	66 (66%)	𝑃=0.0077
ER−	21 (17.7%)	34 (34%)
PR+	81 (68.6%)	50 (50%)	𝑃=0.0057
PR−	37 (31.3%)	50 (50%)
HER2+ (FISH)	36 (30.5%)	23 (23%)	𝑃=0.2859
HER2−	82 (69.4%)	74 (74%)
Ki67 > 10%	78 (66.1%)	84 (84%)	𝑃=0.0030
Ki67 < 10%	40 (33.8%)	16 (16%)
P53 >10%	27 (22.8%)	26 (26%)	𝑃=0.6363
P53 <10%	91 (77.1%)	74 (74%)
Total	118	100

*Chi-square test; 𝑃<0.05 is significant.