A Comparative Analysis of Biomarker Expression and Molecular Subtypes of Pure Ductal Carcinoma In Situ and Invasive Breast Carcinoma by Image Analysis: Relationship of the Subtypes with Histologic Grade, Ki67, p53 Overexpression, and DNA Ploidy

Table 6

A comparison of Ki67 indices and p53 overexpression in the different subtypes of pDCIS and IBCAs.

Tumor type	Luminal-A	Luminal-B	Lum-HER2	HER2	Triple negative	𝑃 value (ANOVA)
DCIS	44 (37.3%)	31 (26.3%)	22 (8.6%)	14 (11.8%)	7 (6%)
Ki67 (%)	6.98 ± 0.52	23.8 ± 2.22	23.27 ± 2.72	33.57 ± 4.87	39.57 ± 13.6	𝑃<0.0001
P53 (%)	7.02 ± 2.89	12.3 ± 3.92	17.8 ± 6.10	24.4 ± 8.53	52.3 ± 18.6	𝑃=0.0014
IBCA	21 (21%)	30 (30%)	15 (15%)	8 (8%)	26 (26%)
Ki67 (%)	7.05 ± 0.75	33.7 ± 2.53	41.4 ± 6.50	58.0 ± 9.46	67.5 ± 6.04	𝑃<0.0001
P53 (%)	2.15 ± 0.81	6.87 ± 2.12	36.3 ± 10.1	23.1 ± 15.1	31.0 ± 8.04	𝑃<0.0001