International Journal of Breast Cancer / 2011 / Article / Tab 6

Research Article

A Comparative Analysis of Biomarker Expression and Molecular Subtypes of Pure Ductal Carcinoma In Situ and Invasive Breast Carcinoma by Image Analysis: Relationship of the Subtypes with Histologic Grade, Ki67, p53 Overexpression, and DNA Ploidy

Table 6

A comparison of Ki67 indices and p53 overexpression in the different subtypes of pDCIS and IBCAs.

Tumor typeLuminal-ALuminal-BLum-HER2HER2Triple negative 𝑃 value (ANOVA)

DCIS44 (37.3%)31 (26.3%)22 (8.6%)14 (11.8%)7 (6%)
 Ki67 (%)6.98 ± 0.5223.8 ± 2.2223.27 ± 2.7233.57 ± 4.8739.57 ± 13.6 𝑃 < 0 . 0 0 0 1
 P53 (%)7.02 ± 2.8912.3 ± 3.9217.8 ± 6.1024.4 ± 8.5352.3 ± 18.6 𝑃 = 0 . 0 0 1 4

IBCA21 (21%)30 (30%)15 (15%)8 (8%)26 (26%)
 Ki67 (%)7.05 ± 0.7533.7 ± 2.5341.4 ± 6.5058.0 ± 9.4667.5 ± 6.04 𝑃 < 0 . 0 0 0 1
 P53 (%)2.15 ± 0.816.87 ± 2.1236.3 ± 10.123.1 ± 15.131.0 ± 8.04 𝑃 < 0 . 0 0 0 1

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