Intraoperative Radiotherapy in the Treatment of Breast Cancer: A Review of the Evidence

Table 1

Summary of evidence regarding the location of in-breast recurrences.

Year	Description	All LR	IBNP	True LR	Reference
2007	5318 patients with early breast cancer; all had lumpectomy and EBRT ± boost	91	17	81%	[36]
1993	567 women ± EBRT, 39 m median FUP. IBNP “>2 cm from primary site”	25	4	84%	[37]
1992	837 women ± EBRT, 43 m median FUP	131	19	85%	[38]
1992	488 women all with lumpectomy plus EBRT, 103 m mean FUP. “True” LR—“at or close to same quadrant as index case”	42	2	95%	[39]
1990	783 women, 80 m median FUP	91	17	81%	[40]
1990	381 women ± EBRT, 30 m FUP	15	2	87%	[41]
1990	496 women, 71 m median FUP	61	15	77%	[42]
1990	1593 women, 11 y median FUP	178	38	79%	[43]
1989	861 women, 5-6 years median FUP	93	19	80%	[44]
1984	231 women, 44 m median FUP	12	2	83%	[45]
1982	680 women	509	3	>99%	[46]
1982	28 women with DCIS treated by biopsy alone, FUP > 3 y	7	1	86%	[47]
1981	176 patients, median FUP 47 m	15	1	93%	[48]

LR = local recurrence (any recurrence in the ipsilateral breast).
IBNP = ipsilateral breast new primary (a LR that is some distance away from the site of the original tumour; precise definitions vary by study).
True LR = (All LR-IBNP)/(All LR) expressed as a percentage.