Review Article
CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis
Table 1
CXCR4 and lymph node metastasis in recent studies.
| Study | Findings | value |
|
Hao et al. [35] | ↑CXCR4 with ↑TNM stage | <0.037 | ↑CXCR4 with +lymph node mets | <0.001 | ↑CXCR4/VEGF w/+LN mets | 0.007 | ↑CXCR4/MMP-9 w/+LN mets | <0.001 |
|
Kang et al. [36] | ↑CXCR4 in +LN tumors over −LN tumors | 0.03 | ↑CXCR w/OS or distant mets-not observed in this data | — |
| Parker et al. [37] | ↑CXCR4 w/+LN had worse 5 yr OS | 0.02 |
| Cabioglu et al. [38] | ↑CXCR4 w/+LN | 0.113 |
| Su et al. [39] | ↑CXCR4 (cytoplasmic) with +LN mets | 0.0325 |
|
|
CXCR4: CXC chemokine receptor 4, LN mets: lymph node metastases, MMP-9: matrix metalloproteinase-9, VEGF: vascular endothelial growth factor.
|