International Journal of Breast Cancer / 2011 / Article / Tab 1

Review Article

CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis

Table 1

CXCR4 and lymph node metastasis in recent studies.

StudyFindings value

Hao et al. [35]↑CXCR4 with ↑TNM stage<0.037
↑CXCR4 with +lymph node mets<0.001
↑CXCR4/VEGF w/+LN mets 0.007
↑CXCR4/MMP-9 w/+LN mets<0.001

Kang et al. [36]↑CXCR4 in +LN tumors over −LN tumors0.03
↑CXCR w/OS or distant mets-not observed in this data

Parker et al. [37]↑CXCR4 w/+LN had worse 5 yr OS0.02

Cabioglu et al. [38]↑CXCR4 w/+LN0.113

Su et al. [39]↑CXCR4 (cytoplasmic) with +LN mets0.0325

CXCR4: CXC chemokine receptor 4, LN mets: lymph node metastases, MMP-9: matrix metalloproteinase-9, VEGF: vascular endothelial growth factor.

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