Table 4: Patients with benign diagnoses at duct excision, who subsequently represented with breast cancer.

Age at original presentationInitial presentationInitial diagnosisTime to re-presentationSideSubsequent presentationFurther histologyTreatment

63Bloodstained single-duct nipple dischargeADH16 monthsContralateralSerous nipple discharge dipstick +++ for blood2 mm grade 2 node negative IDC +DCIS + duct papillomaMx + ANC
77Bloodstained single-duct nipple dischargeADH48 monthsIpsilateralAsymmetric density seen on screening mammogram follow up16 mm grade 2 node negative IDCMx + ANC
49Serous single-duct nipple dischargeDuct papilloma, duct ectasia and fibrocystic disease84 monthsContralateralBreast pain and nodularity23 mm grade 2 node negative IDC + DCISMx + ANC + reconstruction. Recurrence in reconstructio 15 months later treated with WLE + DXT (15 mm grade 3 IDC)
52Bloodstained single-duct nipple dischargeFibrocystic disease94 monthsIpsilateralLump in axillaMetastatic adenocarcinoma from presumed occult breast primaryANC
59Bloodstained single-duct nipple dischargeDuct ectasia54 monthsIpsilateralLump22 mm grade 2 node negative IDCWLE + ANC + DXT
62Brown single-duct nipple dischargeDuct papilloma56 monthsIpsilateralBloodstained nipple dischargeTwo adjacent <5 mm grade 2 node negative IDCMx + ANC
67Serous single-duct nipple dischargeDuct papilloma26 monthsContralateralBloodstained nipple discharge and nodularity13 mm grade 2 node negative IDC, DCIS + multiple duct papillomasWLE + ANS + DXT
76Clear single-duct nipple dischargeDuct papilloma + duct ectasia6 weeksContralateralNew lump14 mm grade 2 node negative IDCMx + ANC

Histology: DCIS: ductal carcinoma in situ; IDC: Invasive ductal carcinoma.
Treatment: Mx: mastectomy; ANS: axillary node sampling; ANC: axillary node clearance; WLE: wide local excision; DXT: radiotherapy.