17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats

Figure 1

% Survival. Seven-week-old female Lewis rats were treated with a single IP injection of 50 mg/kg MNU. Tumors developed for 90 days, prior to treatment (𝑛=13) for 28 days with (a) cyclodextrin vehicle daily, (b) 6.6 mg HE3235 daily, (c) 4 mg HE3235 daily, (d) 6.6 mg HE3235 daily + 1.5 mg docetaxel weekly, (e) 1.5 mg docetaxel weekly, (f) 2.5 mg anastrazole daily, and (g) 0.25 mg tamoxifen weekly. HE3235 in combination with docetaxel was more effective than comparator monotherapies at promoting survival. 𝑌-axis, percent survival; 𝑋-axis, study day. Therapy (Tx) started on Day 101 and ended on Day 128. The first animal was sacrificed on day 139 (vehicle group). *𝑃=.0149 versus docetaxel on day 195.

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