International Journal of Breast Cancer

Review Article

Subgross Morphology, the Sick Lobe Hypothesis, and the Success of Breast Conservation

Table 1

Ipsilateral local recurrence rates by disease extent and type of surgery: extensive tumors defined as those occupying an area 4 cm or larger in the greatest dimension. Falun 1996–1998, 10-year followup.
Extensive tumors ≥4 cmNonextensive tumors <4 cmTotalRelative riskSignificance level
Mastectomy7.3% (9/124)9.3% (8/86)8.1% (17/210) R R = 0 . 7 8 0 2
(CI: 0.3135–1.9429)		 𝑃 = . 5 9 3 7
Breast-conserving surgery20.5% (9/44)7.4% (20/269)8.9% (29/313) R R = 2 . 7 5 1 1
(CI: 1.3401–5.6478)		 𝑃 = . 0 0 5 8
Sum10.7% (18/168)7.9% (28/355)8.6% (46/523) R R = 1 . 3 5 8 4
(CI: 0.7736–2.3852)		 𝑃 = . 2 8 6 2
Relative risk R R = 2 . 8 1 8 2
(CI: 1.1955–6.6435)		 R R = 1 . 2 5 1 2
(CI: 0.5717–2.7380)		 R R = 0 . 8 7 3 7
(CI: 0.4928–1.5490)
Significance level 𝑃 = . 0 1 7 9 𝑃 = . 5 7 4 9 𝑃 = . 6 4 4 0