International Journal of Breast Cancer

Review Article

Subgross Morphology, the Sick Lobe Hypothesis, and the Success of Breast Conservation

Table 2

Ipsilateral local recurrence rates by disease extent and type of surgery: extensive tumors defined as those occupying an area 3 cm or larger in the greatest dimension. Falun 1996–1998, 10-year followup.
Extensive tumors ≥3 cmNonextensive tumors <3 cmSumRelative riskSignificance level
Mastectomy7.5% (12/160)10.0% (5/50)8.1% (17/210) R R = 0 . 7 5 0 0
(CI: 0.2776–2.0261)		 𝑃 = . 5 7 0 7
Breast-conserving surgery15.0% (12/80)7.3% (17/233)9.2% (29/313) R R = 2 . 0 5 5 9
(CI: 1.0271–4.1152)		 𝑃 = . 0 4 1 8
Sum10.0% (24/240)7.8% (22/283)8.8% (46/523) R R = 1 . 2 8 6 4
(CI: 0.7404–2.2349)		 𝑃 = . 3 7 1 6
Relative risk R R = 2 . 0 0 0 0
(CI: 0.9411–4.2502)		 R R = 0 . 7 2 9 6
(CI: 0.2824–1.8851)		 R R = 1 . 1 4 4 5
(CI: 0.6456–2.0291)
Significance level 𝑃 = . 0 7 1 5 𝑃 = . 5 1 5 1 𝑃 = . 6 4 4 0