The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer

Figure 1

Domain structures of IRF1 and IRF2. IRF1 and IRF2 are composed of a DNA-binding domain (DBD; N-terminus) and a regulatory domain (C-terminus). The DBD is characterized by five tryptophan residues each separated by 10–18 amino acids. IRF1 and IRF2 also contain an IRF association domain (IAD). For IRF1, activity depends on phosphorylation, whereas IRF2 contains a repression domain (red). The size of each IRF1 (in amino acids; aa) is also indicated. C: carboxyl terminus; N: amino terminus.