The Role of Aryl Hydrocarbon Receptor and Crosstalk with Estrogen Receptor in Response of Breast Cancer Cells to the Novel Antitumor Agents Benzothiazoles and Aminoflavone

Figure 9

Mode of action of aminoflavone. Aminoflavone binds to cytosolic AhR. Only breast cancer cells with cytosolic AhR form AhR: AF complexes that translocate to the nucleus. Cells with constitutive nuclear AhR expression are not influenced by AF. In the nucleus, AhR: AF complex induces CYP1A1 leading to AF metabolism and DNA-damaging products. AF-sensitive breast cancer cells examined to this point express estrogen receptor (ER). SULT1A1: sulfotransferase 1A1; DSB: double strand breaks [30].