Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies
Figure 1
(a). An example of the general structure an ABC transporter with 2 sets of transmembrane domains (TMD) and 2 nucleotide binding domains (NBD). Substrate molecules are present in the inner membrane shown in orange. Upon binding of ATP, the NBD become joined, leading to a conformational change (b). This change causes the movement of the substrate out of the membrane.
