Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies

Figure 3

Structure of Multidrug Resistance Protein 1 (MRP1)—this ABC transporter is similar in structure to PGP in that they possess 2 ATP binding sites. In addition to the 12 transmembrane domains, they also contain an additional 5 transmembrane domains at the amino terminal end. Other transporters with a similar structure include MRP2, MRP3 and MRP6.