Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies

Table 3

Effect of ABC transporters on patient response rate to chemotherapy.

	All chemotherapy	Cyclophosphamide. Methotrexate and 5-Fluorouracil	5-Fluorouracil, epirubicin/doxorubicin and cyclophospamide
All patients	34/59 (58%)	15/28 (54%)	19/31 (61%)
Low BCRP	27/42 (64%)	11/20 (55%)	16/22 (73%)
High BCRP	7/17 (41%)	4/8 (50%)	3/9 (33%)
Low MRP1	18/30 (60%)	8/16 (50%)	10/14 (71%)
High MRP1	16/29 (55%)	7/12 (58%)	9/17 (53%)
Low MRP2	18/28 (64%)	5/8 (63%)	13/20 (65%)
High MRP2	13/28 (46%)	8/18 (44%)	5/10 (50%)
Low PGP	32/47 (68%)	13/22 (59%)	19/25 (76%)
High PGP	2/12 (17%)	2/6 (33%)	0/6 (0%)