Effects of Auraptene on IGF-1 Stimulated Cell Cycle Progression in the Human Breast Cancer Cell Line, MCF-7

Table 3

Significant GPR fold change in the mRNA of target genes related to cell cycle in IGF-1 + auraptene treated cells compared to cells treated with IGF-1 alone at 8 h.

Gene	Function	GPR fold change
E2F1	Act in the G1/S transition	−7.88
CDC45L	DNA replication	−6.51
E2F2	Act in the G1/S transition	−9.81
MCM3	Integral part of the prereplication complex during cell cycle	−6.08
MCM6	Integral part of the prereplication complex during cell cycle	−3.71
UHRF1	Recruits histone deacetylase during cell cycle. Major role in G1/S transition	−17.01
CDKN2B	Prevent activation of CDK by cyclin D1	5.83
DDIT3	Arresting cell cycle after DNA damage	9.36
JUN	Form AP-1 and promote cell proliferation	3.65