Effects of Auraptene on IGF-1 Stimulated Cell Cycle Progression in the Human Breast Cancer Cell Line, MCF-7
Table 4
Significant GPR fold change in the mRNA of target genes related to cell cycle in IGF-1 + auraptene treated cells compared to cells treated with IGF-1 alone at 24 h (the genes significantly changed at both 8 h and 24 h time points are shown in bold).
Gene
Function
GPR fold change
CDC45L
DNA replication
−20.71
CDC2
Promotes G1/S transition
−38.29
CCNA2
Promotes cell cycle in the mitosis phase
−20.25
KIF20B
Involved in the cytokinesis, the final phase of cell division
−32.48
CHEK1
Inhibits cell division
−9.01
CDKN2C
Inhibits G1/S entry
−8.98
CHEK2
Cell cycle arrest. Activated in response to DNA damage.
−10.83
E2F1
Act in the G1/S transition
−10.44
CCNB2
Promotes cell division, active in G2/M phase
−6.81
UHRF1
Recruits histone deacetylase during cell cycle. Major role in G1/S transition
−45.85
DDIT3
Arresting cell cycle after DNA damage
53.22
CDKN2B
Prevent activation of CDK by cyclin D1
6.14
GADD45A
Participates in arresting cell cycle after DNA damage
10.16
DUSP1
Inactivates MAPK phosphorylation and inhibits proliferation