Effects of Auraptene on IGF-1 Stimulated Cell Cycle Progression in the Human Breast Cancer Cell Line, MCF-7

Table 4

Significant GPR fold change in the mRNA of target genes related to cell cycle in IGF-1 + auraptene treated cells compared to cells treated with IGF-1 alone at 24 h (the genes significantly changed at both 8 h and 24 h time points are shown in bold).

Gene	Function	GPR fold change
CDC45L	DNA replication	−20.71
CDC2	Promotes G1/S transition	−38.29
CCNA2	Promotes cell cycle in the mitosis phase	−20.25
KIF20B	Involved in the cytokinesis, the final phase of cell division	−32.48
CHEK1	Inhibits cell division	−9.01
CDKN2C	Inhibits G1/S entry	−8.98
CHEK2	Cell cycle arrest. Activated in response to DNA damage.	−10.83
E2F1	Act in the G1/S transition	−10.44
CCNB2	Promotes cell division, active in G2/M phase	−6.81
UHRF1	Recruits histone deacetylase during cell cycle. Major role in G1/S transition	−45.85
DDIT3	Arresting cell cycle after DNA damage	53.22
CDKN2B	Prevent activation of CDK by cyclin D1	6.14
GADD45A	Participates in arresting cell cycle after DNA damage	10.16
DUSP1	Inactivates MAPK phosphorylation and inhibits proliferation	7.51