Preclinical Evaluation of Oncolytic Δγ134.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases
Figure 6
Kaplan-Meier plots of antitumor effect of M002 in vivo against intracranial SCK tumors. Tumors were treated four days after establishment with 1.5 × 107 PFU of R3659 or M002, or were given saline only as a control. By log-rank analysis, both R3659-() and M002-treated mice () survived significantly longer than mock-treated mice, and M002-treated mice survived longer than R3659-treated mice (). Median survival times (MSTs) are indicated.
