PKC𝜶 and ER𝜷 Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients

Table 3

(a) Relationship of ERα status and PKCα expression based on race. (b) ERα status and PKCα expression is inversely related.

(a)

Race	Outcome	Median (minimum, maximum)		P value*
		ER(−) (𝑁=80)	ER(+) (𝑁=118)
	PKC (freq)	2 (0, 4)	2 (0, 4)	0.09
AA	PKC (int)	2 (0, 4)	1 (0, 4)	0.01^††
	PKC (sum)	5 (0, 8)	4 (0, 8)	0.02^†
	PKC (freq)	3 (0, 4)	2 (0, 4)	0.02^†
Caucasian	PKC (int)	1.5 (0, 4)	1 (0, 4)	0.38
	PKC (sum)	4.5 (0, 8)	3 (0, 7)	0.07

* 𝑃 value based on the Wilcoxon Rank (sum) Test. ^†𝑃 value <0.05; ^††𝑃 value <0.01.

(b)

Outcome	Median (minimum, maximum)		𝑃 value*
	ER(−)	ER(+)
PKCα (freq)	3 (0, 4)	2 (0, 4)	0.004^††
PKCα (int)	2 (0, 4)	1 (0, 4)	0.012^†
PKCα (sum)	5 (0, 8)	3 (0, 8)	0.002^††

* 𝑃 value based on the Wilcoxon Rank (sum) Test. ^†𝑃 value <0.05; ^††𝑃 value <0.01.