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International Journal of Breast Cancer
Volume 2013, Article ID 101705, 17 pages
http://dx.doi.org/10.1155/2013/101705
Research Article

Mechanisms Mediating the Effects of γ-Tocotrienol When Used in Combination with PPARγ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells

College of Pharmacy, University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 71209, USA

Received 12 September 2012; Revised 20 November 2012; Accepted 29 November 2012

Academic Editor: Heather E. Kleiner-Hancock

Copyright © 2013 Abhita Malaviya and Paul W. Sylvester. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [10 citations]

The following is the list of published articles that have cited the current article.

  • Paul W. Sylvester, Mohamed R. Akl, Abhita Malaviya, Parash Parajuli, Suryatheja Ananthula, Roshan V. Tiwari, and Nehad M. Ayoub, “Potential role of tocotrienols in the treatment and prevention of breast cancer,” BioFactors, 2013. View at Publisher · View at Google Scholar
  • Nik Soriani Yaacob, Rabail Nasir, and Mohd Nor Norazmi, “Influence of 17 beta-Estradiol on 15-Deoxy-Delta(12,14)Prostaglandin J(2)-Induced Apoptosis in MCF-7 and MDA-MB-231 Cells,” Asian Pacific Journal of Cancer Prevention, vol. 14, no. 11, pp. 6761–6767, 2013. View at Publisher · View at Google Scholar
  • Abhita Malaviya, and Paul W. Sylvester, “Synergistic Antiproliferative Effects of Combined γ-Tocotrienol and PPARγ Antagonist Treatment Are Mediated through PPARγ-Independent Mechanisms in Breast Cancer Cells,” PPAR Research, vol. 2014, pp. 1–18, 2014. View at Publisher · View at Google Scholar
  • Yuka Isozaki, Isamu Hoshino, Yasunori Akutsu, Naoyuki Hanari, Mikito Mori, TakanoriNishimori TakanoriNishimori, Kentaro Murakami, Naoki Akanuma, Takeshi Toyozumi, Masahiko Takahashi, Hiroshi Suito, Nobuyoshi Takeshita, Tetsuro Maruyama, Akane Suzuki, Toshinori Nakayama, and Hisahiro Matsubara, “Screening of Alternative Drugs to the Tumor Suppressor miR-375 in Esophageal Squamous Cell Carcinoma Using the Connectivity Map,” Oncology, vol. 87, no. 6, pp. 351–363, 2014. View at Publisher · View at Google Scholar
  • Takahiro Eitsuka, Naoto Tatewaki, Hiroshi Nishida, Kiyotaka Nakagawa, and Teruo Miyazawa, “Synergistic Anticancer Effect of Tocotrienol Combined with Chemotherapeutic Agents or Dietary Components: A Review,” International Journal of Molecular Sciences, vol. 17, no. 10, pp. 1605, 2016. View at Publisher · View at Google Scholar
  • Ibrahim Gayadh Algayadh, Venkateshwararao Dronamraju, and Paul William Sylvester, “Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of γ-Tocotrienol on Mammary Cancer Cell Migration and Invasion,” Biological and Pharmaceutical Bulletin, vol. 39, no. 12, pp. 1974–1982, 2016. View at Publisher · View at Google Scholar
  • Takahiro Eitsuka, Naoto Tatewaki, Hiroshi Nishida, Kiyotaka Nakagawa, and Teruo Miyazawa, “A Combination of δ-Tocotrienol and Ferulic Acid Synergistically Inhibits Telomerase Activity in DLD-1 Human Colorectal Adenocarcinoma Cells,” Journal of Nutritional Science and Vitaminology, vol. 62, no. 5, pp. 281–287, 2016. View at Publisher · View at Google Scholar
  • Osama A. Alawin, Rayan A. Ahmed, Venkateshwararao Dronamraju, Karen P. Briski, and Paul W. Sylvester, “γ-Tocotrienol-Induced Disruption of Lipid Rafts in Human Breast Cancer Cells is Associated with a Reduction in Exosome Heregulin Content,” The Journal of Nutritional Biochemistry, 2017. View at Publisher · View at Google Scholar
  • Han Wu, Shaoping Liu, Jun Gong, Jiuyang Liu, Qian Zhang, Xiaohua Leng, Nian Zhang, and Yan Li, “VCPA, a novel synthetic derivative of α-tocopheryl succinate, sensitizes human gastric cancer to doxorubicin-induced apoptosis via ROS-dependent mitochondrial dysfunction,” Cancer Letters, 2017. View at Publisher · View at Google Scholar
  • Bethsebie Lalduhsaki Sailo, Kishore Banik, Ganesan Padmavathi, Monisha Javadi, Devivasha Bordoloi, and Ajaikumar B Kunnumakkara, “Tocotrienols: The Promising Analogues of Vitamin E for Cancer Therapeutics,” Pharmacological Research, 2018. View at Publisher · View at Google Scholar