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Therapeutic combination | Approval status | Clinical data | Most common grade 3-4 adverse events |
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Trastuzumab plus chemotherapy (doxorubicin or epirubicin plus cyclophosphamide or paclitaxel) (TC) [25] | Phase III Approved | TC versus C alone ORR: 50% versus 32% (P < 0.001) TTP: median 7.4 versus 4.6 months (P < 0.001) TTF: median 6.9 versus 4.5 months (P < 0.001) DR: median 9.1 versus 6.1 months (P < 0.001) Death rate at 1 year: 22% versus 33% (P = 0.008) OS: median 25.1 versus 20.3 months (P = 0.046) | TC versus C alone* Leukopenia: 11% versus 9% Asthenia: 7% versus 7% Fever: 8% versus 4% Pain: 6% versus 7% Heart failure: 10% versus 2% Nausea: 5% versus 7% Vomiting: 5% versus 7% Alopecia: 26% versus 35% |
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Capecitabine plus bevacizumab (XB) [74] | Phase III Not approved in the United States; approved in the European Union | XB versus single-agent X ORR: 19.8 versus 9.1% (P = 0.001) PFS: median 4.86 versus 4.17 months, HR = 0.98 (P = 0.857) OS: median 15.1 months versus 14.5 months (NS) | XB versus single-agent X Diarrhea: 11.8% versus 10.7% Hand-foot syndrome: 27.5% versus 24.2% Hypertension: 17.9% versus 0.5% Thrombotic event: 5.6% versus 3.7% |
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Paclitaxel plus bevacizumab (PB) [26] | Phase III Not approved in the United States; approved in the European Union | PB versus single-agent P ORR: 36.9 versus 21.2% (P < 0.001) PFS: median 11.8 versus 5.9 months, HR = 0.60 (P < 0.001) OS: median 26.7 versus 25.2 months, HR = 0.88 (P = 0.02) | PB versus single-agent P Infection: 9.3% versus 2.9% Fatigue: 9.1% versus 4.9% Sensory neuropathy: 23.5% versus 17.7% Hypertension: 14.8% versus 0% |
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Capecitabine plus lapatinib (XL) [75, 76] | Phase III Approved | XL versus single-agent X ORR: 22% versus 14% (P = 0.09) TTP: median 8.4 versus 4.4 months, HR =0.57 (95% CI: 0.43–0.77; P < 0.001) OS: HR = 0.78 (95% CI: 0.55–1.12; P = 0.177) | XL versus single-agent X [75] Diarrhea: 14% versus 10% Hand-foot syndrome: 12% versus 14% |
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Lapatinib plus trastuzumab (LT) [77–79] | Phase III Not approved | LT versus single-agent L ORR: 10.3% versus 6.9% (P = 0.46) PFS: median 12.0 versus 8.4 weeks, HR = 0.77 (95% CI: 0.6–1.0; P = 0.029) OS: median 60.7 versus 41.4 weeks, HR = 0.74 (95% CI: 0.57–0.97; P = 0.026) | LT versus single-agent L [79] Diarrhea: 7% versus 7% |
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