Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response

Table 5

Results of analyses using the ordinary Cox PH model with stepwise variable selection (𝛼=0.05).

Variables	Hazard ratio (95% CI)	𝑃 value
HR status		<0.001
Negative	1
Positive	4.56 (1.92, 10.80)
ET therapy		<0.001
No	1
Yes	0.16 (0.07, 0.36)
Age		Not selected
Clinical stage		Not selected
IIA/IIB/IIIA
IIIB/IIIC
Clinical response		0.026
SD/PD	1
PR	0.60 (0.36, 0.99)
CR	0.39 (0.19, 0.79)
HER2 status		0.002
Negative	1
Positive	1.97 (1.28, 3.03)
Histological grade		0.002
1 and 2	1
3	1.90 (1.26, 2.87)
Number of lymph node metastases		<0.001
0	1
1 to 3	1.93 (1.04, 3.58)
≥4	7.33 (4.18, 12.85)