Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy
Table 1
Patient characteristics.
Characteristic
Diabetics treated w/metformin
Diabetics treated with other drugs
Nondiabetics treated w/metformin
value
No.
51
28
51
Mean age
60.02
61.89
57.75
Age > 50 years no. (%)
0.457
Yes
44 (86)
23 (82)
39 (76)
No
7 (14)
5 (18)
12 (24)
Race, no. (%)
0.058
White
20 (39)
12 (43)
34 (67)
Black
9 (18)
7 (25)
6 (12)
Other
22 (43)
9 (32)
11 (21)
Breast no. (%)
0.103
Right
25 (49)
18 (64)
20 (39)
Left
26 (51)
10 (36)
31 (61)
Smoker no. (%)
0.462
No
34 (67)
21 (75)
42 (82)
Previous
14 (27)
6 (21)
8 (16)
During RT*
3 (6)
1 (4)
1 (2)
CVD† no. (%)
0.349
Yes
2 (4)
0 (0)
0 (0)
No
49 (96)
28 (100)
51 (100)
Axillary dissection no. (%)
0.045
Yes
22 (39)
8 (29)
21 (41)
No
29 (61)
20 (71)
30 (59)
Grade no. (%)
0.404
Low
7 (14)
4 (14)
3 (6)
Intermediate
12 (24)
10 (36)
17 (33)
High
21 (41)
8 (29)
16 (31)
Unknown
11 (21)
6 (21)
15 (29)
T stage no. (%)
0.103
In situ
6 (12)
1 (4)
0 (0)
1
22 (43)
13 (46)
31 (61)
2
15 (29)
8 (29)
10 (19)
3
1 (2)
2 (7)
3 (6)
4
1 (2)
2 (7)
3 (6)
Unknown
6 (12)
2 (7)
4 (8)
ER†† no. (%)
0.757
Positive
33 (65)
22 (79)
37 (73)
Negative
14 (27)
6 (21)
13 (25)
Unknown
4 (8)
0 (0)
1 (2)
PR no. (%)
1
Positive
31 (61)
19 (68)
34 (67)
Negative
16 (31)
9 (32)
16 (31)
Unknown
4 (8)
0 (0)
1 (2)
Her2 no. (%)
0.050
Yes
6 (12)
2 (7)
15 (29)
No
45 (88)
26 (93)
36 (71)
Separation (>25 cm) (%)
0.007
Yes
28 (55)
9 (32)
13 (25)
No
23 (45)
17 (68)
38 (75)
Radiation Field Design
0.98
2-field
31 (61)
16 (57)
31 (61)
SC
12 (23)
7 (25)
12 (23)
SC + IM
3 (6)
1 (4)
3 (6)
APBI
5 (9)
4 (14)
5 (9)
Fractionation schedule
0.17
Conventional
40 (78)
16 (57)
41 (80)
Hypofractionated
6 (12)
7 (25)
4 (8)
APBI
5 (10)
5 (18)
6 (12)
Dose max (>110%)
0.92
Yes
19 (37)
9 (32)
18 (35)
No
32 (63)
19 (68)
33 (65)
Radiation therapy, collagen vascular disease, estrogen receptor, progesterone receptor, human epidermal growth factor receptor,
SC: supraclavicular nodes, IM: internal nammary nodes, APBI: accelerated partial breast irradiation.
CVD: collagen vascular disease, ER: estrogen receptor, and PR: progesterone receptor. Patients characteristics table using Fisher’s exact test to compare groups. The bold numbers refer to numbers that are statistically significant (<.05) for the variable on the same line (listed on the left).
