Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A

Table 2

The final score of VEGFR-1 expression in breast cancer patients and in patients with benign breast disease.

	LNT+; (𝑁T = 30, 𝑁OT = 29); 𝑁, ratio	LNT−; (𝑁T = 21, 𝑁OT = 17); 𝑁, ratio		BBD; (𝑁BBD = 30); 𝑁, ratio
VEGFR-1 expression score
T
0	1 (3.33)	0 (0.00)	0	25 (83.33)
+1	7 (23.33)	6 (28.57)
+2	16 (53.33)	12 (57.14)	+1	5 (16.67)
+3	6 (20.00)	3 (14.28)
ST
0	2 (6.89)	0 (0.00)	+2	0 (0.00)
+1	17 (58.62)	11 (64.70)
+2	9 (31.03)	6 (35.30)	+3	0 (0.00)
+3	1 (3.45)	0 (0.00)
Differences in VEGFR-1 expression between T and ST (Wilcoxon test), T and BT, and T and BT (Mann-Whitney test)	T/ST; 𝑧=−2.961𝑃=0.003	T/ST; 𝑧=−2.640  𝑃=0.008	TLN+/BT; 𝑃=0.0001	TLN−/BT; 𝑃=0.0001
	TLN+/TLN-		STLN+/BT; 𝑃=0.0001	STLN−/BT; 𝑃=0.0001
	𝑃=0.750

LNT+: patients with positive lymph nodes, LNT−: patients with negative lymph nodes, BBD: benign breast disease patients, T: tumour, ST: surrounding tissue, and BT: breast tissue of patients with benign breast disease.