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International Journal of Breast Cancer
Volume 2013 (2013), Article ID 872743, 16 pages
http://dx.doi.org/10.1155/2013/872743
Review Article

Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines

1Asterand US, 440 Burroughs, Tech One Building, Suite 501, Detroit, MI 48202-3420, USA
2ALN Associates, 170 Mount Vernon Street, Winchester, MA 01890, USA

Received 31 August 2012; Revised 31 October 2012; Accepted 8 November 2012

Academic Editor: Debra A. Tonetti

Copyright © 2013 Nandita Barnabas and Dalia Cohen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We reviewed the phenotypic and molecular characteristics of MCF10DCIS.com and the SUM cell lines based on numerous studies performed over the years. The major signaling pathways that give rise to the phenotype of these cells may serve as a good resource of information when researchers in drug discovery and development use these cells to identify novel targets and biomarkers. Major signaling pathways and mutations affecting the coding sequence are also described providing important information when using these cells as a model in a variety of studies.