International Journal of Breast Cancer

Review Article

Intraoperative Radiotherapy for Breast Cancer: The Lasting Effects of a Fleeting Treatment

Table 2

Selected series comparing the radiographic changes that follow breast intraoperative radiotherapy and whole breast external beam radiotherapy.


Series	Patients	Year	RT^∗ method	IORT technique	Imaging	Outcome time point (months)	Fat necrosis (%)	Seroma (%)	Fibrosis (%)	Calcs. (%)	Edema (%)

Veronesi et al. [7]	651	2013	IORT alone	Electrons	MMG and US	70	15	NR	NR	NR	NR
Veronesi et al. [7]	651	2013	EBRT	Electrons	MMG and US	70	7	NR	NR	NR	NR
Della Sala et al. [43]	90	2006	IORT alone	Electrons	MMG and US	6, 12, 24	11, 42, 44	31, 42, 36	NR	2, 18, 20	50, 7, 0
Della Sala et al. [43]	90	2006	EBRT	Electrons	MMG and US	6, 12, 24	7, 4, 0	11, 4, 0	NR	2, 2, 7	25, 2, 0
Carvalho et al. [44]	60	2011	IORT alone	Electrons	MMG	12, 24	20, 33	NR	43, 47	NR, 60	37, 27
Carvalho et al. [44]	60	2011	EBRT	Electrons	MMG	12, 24	7, 13	NR	37, 23	NR, 47	57, 40
Wasser et al. [45]	54	2007	IORT + EBRT	kV photons	MMG and US	24	52	33	93	22	89
Wasser et al. [45]	54	2007	EBRT	kV photons	MMG and US	24	15	4	93	7	96
Sautter-Bihl et al. [26]	53	2010	IORT + EBRT	Electrons	MMG	NR	50	NR	95	NR	75
Sautter-Bihl et al. [26]	53	2010	EBRT	Electrons	MMG	NR	18	NR	88	NR	91
Engel et al. [46]	48	2013	IORT ± EBRT	kV photons	MMG	52	56	19	85	63	NR
Engel et al. [46]	48	2013	EBRT	kV photons	MMG	52	24	0	95	19	NR

^∗RT: radiotherapy; IORT: intraoperative radiotherapy; calcs.: calcifications; EBRT: external beam radiotherapy; MMG: mammogram; US: ultrasound; NR: not reported; kV: kilovoltage.